Saturday, October 22, 2016

A team of scientists has identified MNX1 as a new oncogene - a gene than can cause cancer - that is more active in African American prostate cancer than in European American prostate cancer

The finding suggests that genetic factors can contribute, at last in part, to the higher incidence of prostate cancer among African American men compared with men of other ethnic groups. "African Americans have about one-and-a-half times the incidence and twice the mortality associated with prostate cancer of European Americans, and the reasons for this are not clear," said senior author Dr. Michael Ittmann, professor of pathology & immunology at Baylor College of Medicine and the Michael E. DeBakey Department of VA Medical Center. Most scientists think that some of the health disparities among ethnic groups can be explained by differences in biology. The scientists discovered that, compared with normal prostate tissues, both African American and European American prostate cancer have MNX1 genes that are more active and produce more of the MNX1 protein. However, MNX1 is significantly more active in African American prostate cancer than in European American prostate cancer. In summary, in African American prostate cancer androgen and the AKT signaling pathway can increase the activity of MNX1, which in turn increases lipid metabolism. Increased lipid metabolism is a hallmark of aggressive prostate cancer, which is more common in African American men.

In the first genome-wide association study (GWAS) of genetic risk factors for inflammatory bowel disease in African Americans, a research team has identified two regions of the genome (loci) associated with ulcerative colitis only in people of African descent

The study identified single-nucleotide polymorphisms (SNPs) - at ZNF649 and at LSAMP - with genome-wide significance in ulcerative colitis. These SNPs are very specific to sub-Saharan Africans and are not found in any other populations - making these findings unique and novel. This is the first time African- specific loci are known to contribute to inflammatory bowel diseases (IBD), and these loci will be added to the already known 200+ loci in IBD to further expand the IBD genetic architecture. The team also found evidence of overlapping genome-wide associations for ulcerative colitis and IBD in African- Americans and other populations. The detection of variants associated with IBD risk in only people of African descent demonstrates the importance of studying the genetics of IBD and other complex diseases in populations beyond those of European ancestry.

German police have arrested a 19-year-old Moroccan migrant on suspicion of raping a 90-year-old woman who had been attending a church service

Dusseldorf police have announced that they had arrested the man after they had launched a search for the assailant after the daylight attack on the grandmother. The elderly woman had left in the church in the heart of the German city center when the assailant pushed her into a narrow alley between two pubs. In the alley, which is usually closed off to the public and used for storing rubbish from the pubs, the perpetrator is said to have demanded money from the woman before sexually assaulting her. Dusseldorf police were able to construct a likeness of the suspect after a police officer recognized the man at a trains station. The DNA of the man, a Moroccan migrant who had previously lived in Spain, matched the traces found at the crime scene. The man had been previously arrested for robbing a teenager in May 2016. The news comes after the chief of the German police union Rainer Wendt said that criminal migrants from north Africa were laughing at the German justice system as they are often allowed to go free after committing crimes. “They despise our country and laugh at our justice,” Wendt said. “If there is no pre-trial detention made, no imprisonment is imposed, and no deportations carried out then the police make multiple arrests and the perpetrators get away with it,” he added and stated that the migrants are often then released. Wendt also referred to the Casablanca Report that documented around 2,244 North African migrant criminals in the city of Dusseldorf and the police union leader stated that the figures were similar for other German cities around the country. Earlier in 2016 refugees burnt down a shelter for asylum seekers in the city amid claims that the fire had been started over a dispute over food.

Thursday, October 20, 2016

Milwaukee: A black police officer who fatally shot another black man in August 2016, sparking several nights of unrest, has been charged with sexually assaulting a man the night after the shooting, after they watched coverage of the riots on television at a bar

Officer Dominique Heaggan-Brown, 24, has been arrested. The alleged victim, unidentified in a criminal complaint, told police on August 15, 2016 that Heaggan-Brown had sexually assaulted him while off duty. Heaggan-Brown fatally shot 23-year-old Sylville Smith on August 13, 2016. Police said that he was holding a gun when he was shot after a brief chase. Police said that Heaggan-Brown is suspended and in custody and they have launched an internal investigation. Police Chief Ed Flynn said that nothing in Heaggan-Brown's pre-hiring background check suggested that he would be likely to engage in wrongdoing. Heaggan-Brown's attorney, Michael Steinle, didn't immediately respond to messages seeking comment. Heaggan-Brown's bail was set at $100,000. He's set to appear at a preliminary hearing on October 27, 2016.

Wednesday, October 19, 2016

Eight members of a South Asian sex gang in Rotherham, England have been convicted of sexually exploiting teenage girls after making them suffer degrading and violent acts

ageer Hussain, 30, openly boasted that he was racist and told his distraught 13-year-old white victim: "All white girls are good for is sex and they are just sl*gs." Sageer was convicted of four rapes and one indecent assault and his elder brother Basharat, 40, of indecent assault against the same girl at Sheffield Crown Court. Six other members of the gang were also found guilty of a further ten charges of sexually abusing the three girls – and face jail when sentenced. Sageer’s victim - who is now 27 - told police, their MP and the then home secretary David Blunkett that she had been repeatedly raped by Sageer. But the allegations were dropped after men threatened to burn down the family home and gang-rape her mother.

Black women under the age of 45 are at increased risk for an aggressive form of breast cancer [estrogen receptor (ER) negative] if they experienced a high number of pregnancies, never breast fed, and/or had higher waist-to-hip ratio

Mortality from breast cancer is markedly higher in African American women as compared to white women in the United States, in part because they are more likely to be diagnosed with ER-negative tumors, which are more aggressive and difficult to treat. African American women are also diagnosed with breast cancer at younger ages.

The largest study of genetic variation in the human Y chromosome has revealed that half of all western European men are descended from an individual male thought to have lived 4,000 years ago

The team of researchers believe that this man was one of the earliest people to rule Europe in the Bronze Age. The study also shows explosive rises in male population numbers between 55,000 and 4,000 years ago. Using data from the 1000 Genomes Project, the study analyses the sequence differences of 1,244 human Y chromosomes from 26 populations around the world. Analyzing the Y chromosome of modern men can help us discover the history of our ancestors. The Y chromosome, which is only passed from father to son, is linked to male characteristics and behaviors. The team of 42 researchers involved in the study used the data from the 1,244 Y chromosomes to build a tree that reveals how the men are related to one another genetically. All the men studied were proven to have descended from a single man who lived approximately 190,000 years ago. Lead author Dr Yali Xue from the Wellcome Trust Sanger Institute said that this pattern tells us that there was an explosive increase in the number of men carrying a certain type of Y chromosome, within just a few generations. They only observed this phenomenon in males, and only in a few groups of men. One of the scientists involved in the study, Dr Chris Tyler-Smith, said that genetics can't tell us why it happened but they know that a tiny number of elite males were controlling reproduction and dominating the population. With half of western Europe descending from just one man, there can only be speculations as to why these increases in population happened. The results reveal that the earliest explosions in population occurred 50,000-55,000 years ago, across Asia and Europe, and a later explosion occurred 15,000 years ago in the Americas. The researchers believe this increase in population may be due to the movement of humans out of Africa and settling in Europe and Asia, where there were plenty of resources allowing the population to thrive. The study states that there was a notable increase in the number of lineages outside Africa around 50,000-55,000 years ago, perhaps reflecting the geographical expansion and differentiation of Eurasian populations as they settled the vast expanse of these continents. Later explosions in population occurred between 4,000 and 8,000 years ago in sub-Saharan Africa, Western Europe, South Asia, and East Asia. The later population increases are thought to be explored by advances in technology. The best explanation is they may have resulted from advances in technology that could be controlled by small groups of men. Wheeled transport, metal working and organized warfare are all candidate explanations that can now be investigated further. The data used in this study was gathered from the 1000 Genomes Project, which ran between 2008 and 2015, creating the largest public catalogue of genetic variation in the human Y chromosome.

Tuesday, October 18, 2016

If the Black Lives Matter crowd really cared about black lives they would work to convince their "brothers" to stop shooting each other, since that is overwhelmingly where most blacks are killed

They might also think a bit about reducing the horrific levels of violent crime that seems to be part and parcel of their manhood ritual, which is why police target them in the first place. Whatever credibility BLM has is wasted when they embrace the cause of thugs like Michael Brown, a six-foot-four 265-pound monster who robbed a convenience store and beat up a clerk before trying to wrestle a gun away from a cop.

A Mexican judge who presided over appeals by drug cartel figures including Joaquin "El Chapo" Guzman has been assassinated while jogging outside his home

Judge Vicente Bermudez, 37, was executed by a gunman who ran up and shot him in the back of the head. The killing happened in Metepec, 40 miles from Mexico City, and was captured by a surveillance camera. The judge had dealt with legal challenges brought by lawyers representing Guzman, the head of the Sinaloa drug cartel. The judge had also dealt with appeals by lawyers on behalf of Miguel Trevino, ex-leader of the Zetas cartel. Trevino is being held at the maximum security Altiplano jail which is close to the judge's home. Guzman's lawyers have filed numerous legal challenges aimed at preventing his extradition to the United States.

Five men and a woman have been found alive on a road in western Mexico with their hands amputated and their foreheads marked with the words "I'm a thief"

The victims were mutilated by a criminal group linked to drug trafficking, which also left a dead man on the road and two bags with the severed hands in Tlaquepaque, near Guadalajara, Mexico's second biggest city, police said. "They're in a delicate state of health," local police commander Roberto Larios said. "Their stumps were wrapped in plastic." Drug cartels often leave the dismembered bodies of victims on roadsides in Mexico, making the discovery of six mutilated people alive all the more unusual. The dead man, 39, was apparently beaten to death and his hands were not cut off. He was married to the woman, who is 44. The other men are aged between 25 and 43. Authorities suspect that the gruesome crime is linked to drug dealing. Two of the victims have rap sheets. Witnesses say that the victims were driven to the site in two vehicles and abandoned there with a note that said "this happened to us for being thieves." The message, signed "anti-thief elite group," also threatens thieves and those who abuse women or children. The western state of Jalisco, where Guadalajara is located, has seen horrific acts of violence in recent years linked to the powerful Jalisco New Generation drug cartel.

Female journalist raped by knife-wielding migrants at Jungle camp in Calais, France

A female interpreter working on a documentary about the plight of vulnerable refugee children has been raped at knife-point in the Calais migrant camp, French police have revealed. The terrified 38-year-old was robbed by three armed men from the Jungle, one of whom raped her whilst the other two threatened her colleague with a blade. The unidentified woman, who was helping a journalist from a French news broadcaster, was attacked in the early hours of this morning at the entrance of the notorious shanty town. French prosecutors have confirmed that they had proof the woman was raped and have collected DNA evidence to help them find the attackers. The trio are believed to be from Afghanistan, and are now on the run from the police. The woman was living in Paris, although originally from Afghanistan, and had been employed to interpret for migrants speaking the Pashtun language which is common in her homeland and neighboring Pakistan. The shocking incident is just the latest example of the extreme violence plaguing the Calais migrant camp, and comes just a day after journalists from Sky News were attacked by asylum seekers hurling rocks.

The European Union has been urged to prepare for the arrival of jihadists if the Islamic State (IS) is driven out of its Iraqi stronghold, Mosul

Security Commissioner Julian King said that even a small number of militants would pose a serious threat. Some of the Islamic militants involved in the deadly Islamic State attack on Paris in November 2015 had recently returned from Syria.